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Worcestershire Acute Hospitals NHS Trust
17- Hydroxy Progesterone
CategoryClinical Biochemistry
Test information
Diagnosis of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency in neonates and children. Premature or stressed infants may have 17a-OHP levels up to 40 nmol/L whereas untreated 21-hydroxylase deficiency levels are usually >100 nmol/L. 
Assessing hirsute womem with raised serum FAI and DHEAS levels, or as suggested from a urine steroid profile, for possible late-onset CAH. Monitoring response to treatment of CAH children. 
Blood should be taken before the first morning dose of corticosteroids.
Early morning sample and, if neonate, not before 48 hours. Higher levels if premature. Blood sample should be taken before any emergency administration of corticosteroids. Adult female collect during follicular phase.
Reference range
Units: nmol/L, Neonates (>48 hrs): <8.0 ; Tanner Stage 1 male and female: <5.0 ; Adult males 1.2 - 5.0 ; Adult females 0.6 - 4.0 (follicular phase), 1.0 - 6.0 (luteal phase).
Special requirements
Tube type
Gold top tube
Minimum volume
250 uL
TAT Inpatient
4 weeks
TAT GP/Outpatient
4 weeks
Referral lab
Department of Clinical Biochemistry, Queen Elizabeth Hospital, Birmingham
Page last updated: 11 January 2022