17- Hydroxy Progesterone

17HP

Diagnosis of Congenital Adrenal Hyperplasia (CAH) due to 21-hydroxylase deficiency in neonates and children. Premature or stressed infants may have 17a-OHP levels up to 40 nmol/L whereas untreated 21-hydroxylase deficiency levels are usually >100 nmol/L. 
Assessing hirsute womem with raised serum FAI and DHEAS levels, or as suggested from a urine steroid profile, for possible late-onset CAH. Monitoring response to treatment of CAH children. 
Blood should be taken before the first morning dose of corticosteroids.

Early morning sample and, if neonate, not before 48 hours. Higher levels if premature. Blood sample should be taken before any emergency administration of corticosteroids. Adult female collect during follicular phase.

Units: nmol/L, Neonates (>48 hrs): <8.0 ; Tanner Stage 1 male and female: <5.0 ; Adult males 1.2 - 5.0 ; Adult females 0.6 - 4.0 (follicular phase), 1.0 - 6.0 (luteal phase).

Serum

SST

250 uL

4 weeks

4 weeks

Department of Clinical Biochemistry, Queen Elizabeth Hospital, Birmingham