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Worcestershire Acute Hospitals NHS Trust
6-Thioguanine Nucleotides
CategoryClinical Biochemistry
Test information
Assessment of the therapeutic levels of thioguanine drugs that are being achieved. Of paricular use in patients who are heterozygous for the TPMT enzyme where reduced dose regimes are being used or where it is unclear that therapeutic levels are being achieved.
It is suggested that the level of 6-TGNs is checked 4 weeks after commencing/changing the thiopurine drug dose as by this time steady state levels should have been achieved. Time of sampling need not be related to the time of administration of the parent drug.
Reference range
see report
Special requirements
Whole blood EDTA
Tube type
Purple top tube
Minimum volume
4 mL
TAT Inpatient
2 weeks
TAT GP/Outpatient
2 weeks
Referral lab
Clinical Biochemistry City Hospital Birmingham
Page last updated: 11 January 2022