Aldo/Renin Studies

CONN

The test is most sensitive when used in patients from whom samples are collected in the morning after patients have been out of bed for at least 2h, usually after they have been seated for 5-15 min. Ideally, patients should have unrestricted dietary salt intake and attempt to correct hypokalaemia before testing. 
Withdraw agents that markedly affect the ARR for at least 4 weeks: (a) spironolactone, eplerenone, amiloride and triamterene;(b) potassium-wasting diuretics; (c) products derived from licorice root. Other drugs that may need to be withdrawn for 2 weeks are: ?-adrenergic blockers, central ?-2 agonists, NSAIDS, ACE inhibitors, angiotensin receptor blockers, renin inhibitors, dihydropyridine calcium channel antagonists.

Do not collect on ice, because this will promote conversion of inactive renin to active renin. Sample must be received in lab within 4h collection

Plasma

Li Hep

800 uL

4 weeks

4 weeks

Dept of Clinical Biochemistry, Charing Cross Hospital