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Worcestershire Acute Hospitals NHS Trust
Autoantibody Screen (includes: ANA, Smooth Muscle, Mitochondrial and Liver Kidney Antibodies)
Referral code
Test information
Liver kidney microsomal ab's (LKM) are positive in autoimmune chronic active hepatitis. 
Mitochondrial ab's M2 type is present in >95% of cases of primary biliary cirrhosis. Other types are associated with a wide range of conditions. 
Smooth muscle ab's These are present in high titres in 50-70% of patients with type 1 autoimmune hepatitis. They may also be seen in other types of autoimmune hepatitis, primary biliary cirrhosis and chronic viral hepatitis. 
Special requirements
Plasma or Serum
Tube type
SST, Plain or Lithium Heparin
Gold, red and green top tubes
Assay frequency
Twice weekly
TAT GP/Outpatient
up to 7 days
Referral lab
Immunology Russells Hall Hospital
Page last updated: 11 January 2022