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Worcestershire Acute Hospitals NHS Trust
C.Difficile Antigen
CategoryMicrobiology - Virology
Request form
Please include all relevant clinical details, including any current antibiotic treatment. If the patient is currently in hospital, please specify whether the patient has been in hospital for more or less than 3 days.
Test information
Stage 1: GDH antigen testing. This test detects a cell wall antigen common to all strains of C. difficile. If the result is negative, no further testing is required and the lab will issue a negative report. 
Stage 2 and 3: If the stool sample is GDH positive, a toxin assay/PCR test will be performed to confirm if the strain is able to produce the disease-causing toxin. 
If a delay occurs in delivering the sample to the laboratory, please refrigerate. 
Only unformed stools will be tested for C. difficile. 
If C. difficile is suspected do NOT wait for the test result before isolating the patient and commencing anti C. treatment, particularly in patients who are systemically unwell. 
Special requirements
Patients who have tested positive in the last 28 days will not be retested. In addition, patients who tested negative in the last 7 days will not be retested unless express permission is sought from a medical microbiologist.
Tube type
Sterile stool container
Faecal stools container
TAT Inpatient
Same-day result if the specimen is received before 11am. Testing is performed 7 days a week, 365 day
Referral lab
Page last updated: 11 January 2022